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Androgen Receptor (ANDR) AntibodyPeptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP2509a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
Androgen Receptor (ANDR) Antibody - Product info | |
| Application | WB, IHC
|
| Primary Accession | P10275 |
| Other Accession | Q9GKL7, P19091, O97952, Q5JUN9 |
| Reactivity | Human, Mouse |
| Predicted | Pig, Monkey |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 98989 Da |
Androgen Receptor (ANDR) Antibody - Additional info | |
| Gene ID 367 | |
| Other Names Androgen receptor; AR | |
| Target/Specificity This ANDR antibody is generated from rabbits immunized with the KLH conjugated synthetic peptide HPHARIKLENPLD containing a predicted sumoylation site from the central region of human ANDR. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Androgen Receptor (ANDR) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Androgen Receptor (ANDR) Antibody - Protein Information | |
| Name AR | |
| Synonyms DHTR, NR3C4 | |
| Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | |
| Cellular Location Nucleus. Cytoplasm. Note=Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of GNB2L1 | |
| Tissue Location Isoform 2 is mainly expressed in heart and skeletal muscle | |
Androgen Receptor (ANDR) Antibody - Related products
AP2509a: Androgen Receptor (ANDR) Antibody
AP10111c: AR Antibody (Center)
AP13058c: AR Antibody (Center)
AP13255c: AR Antibody (Center)
BP10111c: AR Antibody (Center) Blocking peptide
Androgen Receptor (ANDR) Antibody - Application data
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ANDR (Cat. #AP2509a) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the AR antibody detected the AR protein (arrow).
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ANDR Antibody (Sumo-site) (Cat. #AP2509a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the ANDR antibody detected the ANDR protein (arrow).
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Androgen Receptor Antibody (ANDR) (Cat. #AP2509a)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Androgen Receptor Antibody (ANDR) for immunohistochemistry. Clinical relevance has not been evaluated.
Androgen Receptor (ANDR) Antibody - Research Areas
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BACKGROUND
Androgen receptor (ANDR) has 3 major functional domains: the N-terminal domain, DNA-binding domain, and an androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The gene for this protein contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of the protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations are also associated with complete androgen insensitivity (CAIS). PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor; sumoylation of ANDR represses androgen receptor dependent transcription.
REFERENCES
Nishida, et al. J. Biol. Chem. 277 (44), 41311-41317 (2002) Sills, E.S., et al., Int. J. Mol. Med. 9(1):45-48 (2002). Chavez, B., et al., J. Hum. Genet. 46(10):560-565 (2001). Ahmed, S.F., et al., J. Clin. Endocrinol. Metab. 85(2):658-665 (2000). Marcelli, M., et al., Cancer Res. 60(4):944-949 (2000).
