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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   NYREN18 Antibody (N-term)   

NYREN18 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NYREN18 Antibody (N-term) AP2510a
    The anti-NYREN18 N-term Pab (Cat. #AP2510a) is used in Western blot to detect NYREN18 in mouse liver lysate.
  • WB - NYREN18 Antibody (N-term) AP2510a
    Western blot analysis of NUB1 (arrow) using NYREN18 Antibody (N-term) (Cat.#AP2510a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NUB1 gene (Lane 2) (Origene Technologies).
  • IHC-P - NYREN18 Antibody (N-term) AP2510a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
  • WB - NYREN18 Antibody (N-term) AP2510a
    NYREN18 Antibody (E102) (Cat. #AP2510a) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the NYREN18 antibody detected the NYREN18 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y5A7
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 70538 Da
Antigen Region 87-117 aa
Additional Information
Gene ID 51667
Other Names NEDD8 ultimate buster 1, Negative regulator of ubiquitin-like proteins 1, Renal carcinoma antigen NY-REN-18, NUB1, NYREN18
Target/Specificity This NYREN18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-117 amino acids from the N-terminal region of human NYREN18.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNYREN18 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NUB1
Synonyms NYREN18
Function Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.
Cellular Location Nucleus. Note=Predominantly nuclear
Tissue Location Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2
Research Areas
Citations (0)

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NYREN18 is a specific down-regulator of the NEDD8 conjugation system. It recruits NEDD8 and its conjugates to the proteasome for degradation. It also interacts with PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome.


Tanaka, T., et al., J. Biol. Chem. 278(35):32905-32913 (2003).
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
Kito, K., et al., J. Biol. Chem. 276(23):20603-20609 (2001).
Kamitani, T., et al., J. Biol. Chem. 276(49):46655-46660 (2001).
Scanlan, M.J., et al., Int. J. Cancer 83(4):456-464 (1999).

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$ 295.00
$ 99.00
Cat# AP2510a
(40 western blots)
Availability: In Stock
Bulk Size
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