|Application ||WB, IHC-P, E|
|Calculated MW||70538 Da|
|Antigen Region||513-542 aa|
|Other Names||NEDD8 ultimate buster 1, Negative regulator of ubiquitin-like proteins 1, Renal carcinoma antigen NY-REN-18, NUB1, NYREN18|
|Target/Specificity||This NYREN18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 513-542 amino acids from the C-terminal region of human NYREN18.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NYREN18 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.|
|Cellular Location||Nucleus. Note=Predominantly nuclear|
|Tissue Location||Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
NYREN18 is a specific down-regulator of the NEDD8 conjugation system. It recruits NEDD8 and its conjugates to the proteasome for degradation. It also interacts with PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome.
Tanaka, T., et al., J. Biol. Chem. 278(35):32905-32913 (2003).
Akey, D.T., et al., Hum. Mol. Genet. 11(22):2723-2733 (2002).
Kito, K., et al., J. Biol. Chem. 276(23):20603-20609 (2001).
Scanlan, M.J., et al., Int. J. Cancer 83(4):456-464 (1999).
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