- Antibodies
- New
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Tag
- Peptides
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Amino Acids
- Tag
- Biological Process >
- Proteins
- RNAi
- FL cDNA Clones
- Cell/Tissues/Lysates
NYREN18 Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
Australia Austria Belgium Brazil Bulgaria Canada China Croatia Cyprus Czech Republic Denmark Estonia Finland France Germany Greece Hungary Iceland India Indonesia Ireland Israel Italy Japan Korea Latvia Lithuania Luxembourg Macedonia Malaysia Malta Netherlands Norway Pakistan Poland Portugal Romania Serbia Singapore Slovakia Slovenia Spain Sweden Switzerland Taiwan Turkey United Kingdom United States Vietnam Others 
|
|||
|---|---|---|---|---|
| Catalog # | Size | Availability | Price | |
| AP2510b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
NYREN18 Antibody (C-term) - Product info | |
| Application | WB, IHC
|
| Primary Accession | Q9Y5A7 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 70538 Da |
NYREN18 Antibody (C-term) - Additional info | |
| Gene ID 51667 | |
| Other Names NUB1; NYREN18; NEDD8 ultimate buster 1; Negative regulator of ubiquitin-like proteins 1; Renal carcinoma antigen NY-REN-18 | |
| Target/Specificity This NYREN18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 520~550 amino acids from the C-terminal region of human NYREN18. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions NYREN18 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
NYREN18 Antibody (C-term) - Protein Information | |
| Name NUB1 | |
| Synonyms NYREN18 | |
| Function Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2 | |
| Cellular Location Nucleus. Note=Predominantly nuclear. | |
| Tissue Location Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2 | |
NYREN18 Antibody (C-term) - Related products
AP2510a: NYREN18 Antibody (N-term)
AP2510b: NYREN18 Antibody (C-term)
NYREN18 Antibody (C-term) - Application data
-
The anti-NYREN18 Pab (Cat. #AP2510b) is used in Western blot to detect NYREN18 in 293 cell lysate.
-
Western blot analysis of NUB1 (arrow) using NYREN18 Antibody (C-term) (Cat.#AP2510b).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NUB1 gene (Lane 2) (Origene Technologies).
-
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
NYREN18 Antibody (C-term) - Research Areas
Abgent welcomes feedback from its customers.
If you have used an Abgent product and would like to share how it has performed, please click on the
"Submit Review" button and provide the requested information. Our staff will examine and post your
review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abgent.com.
Thank you for your support.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
NYREN18 is a specific down-regulator of the NEDD8 conjugation system. It recruits NEDD8 and its conjugates to the proteasome for degradation. It also interacts with PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome.
REFERENCES
Tanaka, T., et al., J. Biol. Chem. 278(35):32905-32913 (2003). Akey, D.T., et al., Hum. Mol. Genet. 11(22):2723-2733 (2002). Kito, K., et al., J. Biol. Chem. 276(23):20603-20609 (2001). Scanlan, M.J., et al., Int. J. Cancer 83(4):456-464 (1999).
