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CBX4 Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP2514b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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CBX4 Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | O00257 |
| Other Accession | O55187 |
| Reactivity | Human |
| Predicted | Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 61368 Da |
CBX4 Antibody (C-term) - Additional info | |
| Gene ID 8535 | |
| Other Names CBX4; E3 SUMO-protein ligase CBX4; Chromobox protein homolog 4; Polycomb 2 homolog | |
| Target/Specificity This CBX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 415~444 amino acids from the C-terminal region of human CBX4. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CBX4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
CBX4 Antibody (C-term) - Protein Information | |
| Name CBX4 | |
| Function E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression | |
| Cellular Location Nucleus. Nucleus speckle. | |
| Tissue Location Ubiquitous. | |
CBX4 Antibody (C-term) - Related products
AP17028a: CBX4 Antibody (N-term)
AP2514a: PC2 (CBX4) Antibody (N-term)
AP2514b: CBX4 Antibody (C-term)
DC03981: Human CBX4 cDNA Clone
LY13976a: CBX4 Over-expression Lysate
CBX4 Antibody (C-term) - Application data
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The anti-CBX4 C-term Pab (Cat. #AP2514b) is used in Western blot to detect CBX4 in Jurkat cell lysate.
CBX4 Antibody (C-term) - Research Areas
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BACKGROUND
Chromobox homolog 4 (CBX4 or Pc2) is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of appropriate expression patterns of developmental master regulators and thus are essential for proper development. Changes in expression pf PcG proteins have been associated with cancer. CBX4 is a part of the cellular memory system that is responsible for the inheritance of gene activity by progeny cells. CBX4 is involved in maintaining the transcriptionally repressive state of genes. It modifies chromatin, rendering it heritably changed in its expressibility. Structurally, CBX4 contains 1 chromo domain. It was reported that Pc2 is involved in sumoylation process by recruiting SUMO E1 and E2, and Pc2 is actually SUMO E3 during sumoylation events. CBX4 expression is ubiquitous.
REFERENCES
Kagey, M.H., et al., Cell 113(1):127-137 (2003). Satijn, D.P., et al., Mol. Cell. Biol. 17(10):6076-6086 (1997).
