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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MARCKS Antibody (C-term)   

MARCKS Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MARCKS Antibody (C-term) AP2521b
    Western blot analysis of hMARCKS-K254 (Cat. #AP2521b) in Hela cell line lysates (35ug/lane). MARCKS (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P29966
Other Accession NP_002347
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 31555 Da
Antigen Region 241-271 aa
Additional Information
Gene ID 4082
Other Names Myristoylated alanine-rich C-kinase substrate, MARCKS, Protein kinase C substrate, 80 kDa protein, light chain, 80K-L protein, PKCSL, MARCKS, MACS, PRKCSL
Target/Specificity This MARCKS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-271 amino acids from the C-terminal region of human MARCKS.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMARCKS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
Cellular Location Cytoplasm, cytoskeleton. Membrane; Lipid-anchor
Research Areas
Citations (0)

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MARCKS is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.


Rauch, M.E., et al., J. Biol. Chem. 277(16):14068-14076 (2002).
Aderem, A., Biochem. Soc. Trans. 23(3):587-591 (1995).
Rao, P.H., et al., Cytogenet. Cell Genet. 66(4):272-273 (1994).
Taniguchi, H., et al., J. Biol. Chem. 268(14):9960-9963 (1993).
Blackshear, P.J., J. Biol. Chem. 268(3):1501-1504 (1993).

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Cat# AP2521b
(40 western blots)
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