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ACOX1 Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP2523b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
ACOX1 Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | Q15067 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 74424 Da |
ACOX1 Antibody (C-term) - Additional info | |
| Gene ID 51 | |
| Other Names ACOX1; ACOX; Peroxisomal acyl-coenzyme A oxidase 1; Palmitoyl-CoA oxidase; Straight-chain acyl-CoA oxidase | |
| Target/Specificity This ACOX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 631~660 amino acids from the C-terminal region of human ACOX1. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ACOX1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ACOX1 Antibody (C-term) - Protein Information | |
| Name ACOX1 | |
| Synonyms ACOX | |
| Function Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA | |
| Cellular Location Peroxisome. | |
| Tissue Location Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart | |
ACOX1 Antibody (C-term) - Related products
AM1847a: ACOX1 Antibody (Ascites)
AP2523a: ACOX1 Antibody (N-term)
AP2523b: ACOX1 Antibody (C-term)
RI10070: ACOX1 predesign siRNA
DC02927: Human ACOX1 cDNA Clone
LY12313a: ACOX1 Over-expression Lysate
ACOX1 Antibody (C-term) - Application data
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Western blot analysis of ACOX1 (arrow) using rabbit polyclonal ACOX1 Antibody (C-term) (RB04651). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACOX1 gene (Lane 2) (Origene Technologies).
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Western blot analysis of ACOX1 (arrow) using rabbit polyclonal ACOX1 Antibody (C-term) (RB04652). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACOX1 gene (Lane 2) (Origene Technologies).
ACOX1 Antibody (C-term) - Research Areas
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BACKGROUND
ACOX1 is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids.
REFERENCES
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002). Chu, R., et al., J. Biol. Chem. 270(9):4908-4915 (1995). Aoyama, T., et al., Biochem. Biophys. Res. Commun. 198(3):1113-1118 (1994). Fournier, B., et al., J. Clin. Invest. 94(2):526-531 (1994). Varanasi, U., et al., Proc. Natl. Acad. Sci. U.S.A. 91(8):3107-3111 (1994).
