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CPT1B Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q92523 |
| Other Accession | NP_004368 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 87801 Da |
| Antigen Region | 606-637 aa |
| Gene ID | 1375 |
|---|---|
| Other Names | Carnitine O-palmitoyltransferase 1, muscle isoform, CPT1-M, Carnitine O-palmitoyltransferase I, muscle isoform, CPT I, CPTI-M, Carnitine palmitoyltransferase 1B, Carnitine palmitoyltransferase I-like protein, CPT1B, KIAA1670 |
| Target/Specificity | This CPT1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 606-637 amino acids from the C-terminal region of human CPT1B. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CPT1B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CPT1B |
|---|---|
| Synonyms | KIAA1670 |
| Function | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. |
| Cellular Location | Mitochondrion outer membrane; Multi-pass membrane protein |
| Tissue Location | Strong expression in heart and skeletal muscle. No expression in liver and kidney |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
CPT1B is a member of the carnitine/choline acetyltransferase family, and is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria.
References
Dai, J., et al., Biochem. Biophys. Res. Commun. 301(3):758-763 (2003).
van der Leij, F.R., et al., J. Biol. Chem. 277(30):26994-27005 (2002).
Hirosawa, M., et al., DNA Res. 8(1):1-9 (2001).
Yamazaki, N., et al., J. Biol. Chem. 275(41):31739-31746 (2000).
Britton, C.H., et al., Genomics 40(1):209-211 (1997).
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