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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Serine Palmitoyltransferase (SPTLC2) Antibody (C-term)   

Serine Palmitoyltransferase (SPTLC2) Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Serine Palmitoyltransferase (SPTLC2) Antibody (C-term) AP2533b
    The anti-SPTLC2 Pab (Cat. #AP2533b) is used in Western blot to detect SPTLC2 in mouse liver tissue lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15270
Other Accession P97363, O54694, NP_004854
Reactivity Human, Mouse
Predicted Hamster
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 62924 Da
Antigen Region 531-562 aa
Additional Information
Gene ID 9517
Other Names Serine palmitoyltransferase 2, Long chain base biosynthesis protein 2, LCB 2, Long chain base biosynthesis protein 2a, LCB2a, Serine-palmitoyl-CoA transferase 2, SPT 2, SPTLC2, KIAA0526, LCB2
Target/Specificity This Serine Palmitoyltransferase (SPTLC2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-562 amino acids from the C-terminal region of human Serine Palmitoyltransferase (SPTLC2).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSerine Palmitoyltransferase (SPTLC2) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0526, LCB2
Function Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate.
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Serine palmitoyltransferase (SPT) is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine.


Stachowitz, S., et al., J. Invest. Dermatol. 119(5):1048-1052 (2002).
Dias Neto, E., et al., Proc. Natl. Acad. Sci. U.S.A. 97(7):3491-3496 (2000).
Weiss, B., et al., Eur. J. Biochem. 249(1):239-247 (1997).
Hillier, L.D., et al., Genome Res. 6(9):807-828 (1996).
Takeda, J., et al., Hum. Mol. Genet. 2(11):1793-1798 (1993).

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Cat# AP2533b
(40 western blots)
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