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SPTLC1 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SPTLC1 Antibody (N-term) AP2534a
    Western blot analysis of hSPTLC1-S41 (Cat. #AP2534a) in 293, Hela, K562 cell line and mouse liver tissue lysates (35ug/lane). SPTLC1 (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15269
Other Accession Q60HD1
Reactivity Human, Mouse
Predicted Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 52744 Da
Antigen Region 26-57 aa
Additional Information
Gene ID 10558
Other Names Serine palmitoyltransferase 1, Long chain base biosynthesis protein 1, LCB 1, Serine-palmitoyl-CoA transferase 1, SPT 1, SPT1, SPTLC1, LCB1
Target/Specificity This SPTLC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-57 amino acids from the N-terminal region of human SPTLC1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSPTLC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms LCB1
Function Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein
Tissue Location Widely expressed. Not detected in small intestine.
Research Areas
Citations (0)

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Serine palmitoyltransferase (SPT) is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine.


Stachowitz, S., et al., J. Invest. Dermatol. 119(5):1048-1052 (2002).
Nicholson, G.A., et al., Am. J. Hum. Genet. 69(3):655-659 (2001).
Dawkins, J.L., et al., Nat. Genet. 27(3):309-312 (2001).
Bejaoui, K., et al., Nat. Genet. 27(3):261-262 (2001).
Perry, D.K., et al., J. Biol. Chem. 275(12):9078-9084 (2000).

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$ 295.00
$ 99.00
Cat# AP2534a
(40 western blots)
Availability: In Stock
Bulk Size
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