|Application ||WB, E|
|Calculated MW||33085 Da|
|Antigen Region||1-30 aa|
|Other Names||Sulfotransferase 4A1, ST4A1, 282-, Brain sulfotransferase-like protein, hBR-STL, hBR-STL-1, Nervous system sulfotransferase, NST, SULT4A1, SULTX3|
|Target/Specificity||This SULT4A1a/b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SULT4A1a/b.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SULT4A1a/b Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.|
|Tissue Location||Highly expressed in the cerebral cortex and frontal lobe, slightly less in the cerebellum, occipital and temporal lobes, relatively low in the medulla and putamen, and lowest in the spinal cord. No expression detected in the pancreas (PubMed:10698717). Highly expressed in fetal brain and occipital lobe, slightly less in the whole brain, frontal lobe, hippocampus, and lung, very low expression in cerebellum, medulla oblongata, temporal lobe, testis, kidney and appendix (PubMed:12039030)|
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Provided below are standard protocols that you may find useful for product applications.
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure(number and length of exons) is similar among family members. SULT4A1 isoforms a and b are selectively expressed in brain tissue. Isoform a is the predominant of the two isoforms of this protein. Isoform b includes an alternate segment, compared to isoform a, that causes a frameshift. The resulting protein (isoform b) has a distinct and shorter C-terminus when compared to isoform a.
Liyou, N.E., et al., J. Histochem. Cytochem. 51(12):1655-1664 (2003).
Weinshilboum, R.M., et al., FASEB J. 11(1):3-14 (1997).
Glatt, H., et al., Mutat. Res. 482 (1-2), 27-40 (2001).
Sakakibara, Y., et al., Gene 285 (1-2), 39-47 (2002).
Glatt, H., et al., Toxicol. Lett. 112-113, 341-348 (2000).
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