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CCND1 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CCND1 Antibody (N-term) AP2612a
    Western blot analysis of anti-CCND1 Pab (Cat.#AP2612a) in mouse lung tissue lysates (35ug/lane). CCND1(arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q6FI00
Other Accession P39948, P25322, P24385
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 33729 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 595
Other Names CCND1 protein; Cyclin D1, isoform CRA_c; cDNA, FLJ93625, Homo sapiens cyclin D1 (PRAD1: parathyroid adenomatosis 1) (CCND1), mRNA; Cyclin D1; PRAD1: parathyroid adenomatosis 1; CCND1
Target/Specificity This CCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CCND1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCND1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCND1 {ECO:0000313|EMBL:CAG38775.1}
Cellular Location Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus membrane {ECO:0000256|ARBA:ARBA00004126}
Research Areas
Citations (0)
citation

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Background

CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of the gene encoding this protein, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

References

He,Y.Y., Cancer Res. 68 (10), 3752-3758 (2008)
Marsit,C.J., Clin. Cancer Res. 14 (8), 2371-2377 (2008)
Caldon,C.E., Cancer Res. 68 (8), 3026-3036 (2008)

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Discontinued
Cat# AP2612a
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