|Application ||WB, E|
|Calculated MW||38160 Da|
|Antigen Region||323-354 aa|
|Other Names||Protein atonal homolog 1, Class A basic helix-loop-helix protein 14, bHLHa14, Helix-loop-helix protein hATH-1, hATH1, ATOH1, ATH1, BHLHA14|
|Target/Specificity||This MATH1/HATH1/ATOH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323-354 amino acids from the C-terminal region of human MATH1/HATH1/ATOH1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MATH1/HATH1/ATOH1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
ATOH1 belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47.
Aragaki,M.,Biochem. Biophys. Res. Commun. 368 (4), 923-929 (2008)
Scheffer,D., FEBS Lett. 581 (24), 4651-4656 (2007)
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