|Application ||WB, E|
|Calculated MW||72732 Da|
|Antigen Region||26-57 aa|
|Other Names||Eomesodermin homolog, T-box brain protein 2, T-brain-2, TBR-2, EOMES, TBR2|
|Target/Specificity||This EOMES (TBR2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-57 amino acids from the N-terminal region of human EOMES (TBR2).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EOMES (TBR2) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.|
|Tissue Location||Expressed in CD8+ T-cells.|
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Provided below are standard protocols that you may find useful for product applications.
This protein is a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar protein disrupted in mice is shown to be essential during trophoblast development and gastrulation.
Baala,L., Nat. Genet. 39 (4), 454-456 (2007)
Intlekofer,A.M.,Nat. Immunol. 6 (12), 1236-1244 (2005)
Kimura,N., Brain Res. Dev. Brain Res. 115 (2), 183-193 (1999)
Yi,C.H.,Genomics 55 (1), 10-20 (1999)
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