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QKI Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - QKI Antibody (N-term) AP2707a
    Western blot analysis of anti-QKI Pab (Cat.#AP2707a) in Jurkat cell line lysates (35ug/lane). QKI (arrow) was detected using the purified Pab.
  • IHC-P - QKI Antibody (N-term) AP2707a
    Formalin-fixed and paraffin-embedded human brain tissue reacted with QKI Antibody (N-term) (Cat.#AP2707a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96PU8
Other Accession Q5W9D5, Q9QYS9, Q5W9D7, Q6P104, Q32NN2, Q5W9D6
Reactivity Human
Predicted Xenopus, Zebrafish, Bovine, Mouse, Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 37671 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 9444
Other Names Protein quaking, Hqk, HqkI, QKI, HKQ
Target/Specificity This QKI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human QKI.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsQKI Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name QKI
Synonyms HKQ
Function RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).
Cellular Location Nucleus. Cytoplasm
Tissue Location Expressed in the frontal cortex of brain. Down-regulated in the brain of schizophrenic patients
Research Areas
Citations (0)

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QKI belongs to a family of RNA-binding proteins that have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1) and SF1.


Zhao,L., J. Neurosci. 26 (44), 11278-11286 (2006)
Haroutunian,V., Am J Psychiatry 163 (10), 1834-1837 (2006)
Aberg,K., Proc. Natl. Acad. Sci. U.S.A. 103 (19), 7482-7487 (2006)

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$ 295.00
$ 99.00
Cat# AP2707a
(40 western blots)
Availability: In Stock
Bulk Size
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