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DAX1 (NR0B1) Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP2708b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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DAX1 (NR0B1) Antibody (C-term) - Product info | |
| Application | WB
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| Primary Accession | P51843 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 51718 Da |
DAX1 (NR0B1) Antibody (C-term) - Additional info | |
| Gene ID 190 | |
| Other Names NR0B1; AHC; DAX1; Nuclear receptor subfamily 0 group B member 1; DSS-AHC critical region on the X chromosome protein 1; Nuclear receptor DAX-1 | |
| Target/Specificity This DAX1 (NR0B1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311~341 amino acids from the C-terminal region of human NROB1. | |
| Dilution WB~~1:%0~100WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions DAX1 (NR0B1) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
DAX1 (NR0B1) Antibody (C-term) - Protein Information | |
| Name NR0B1 | |
| Synonyms AHC, DAX1 | |
| Function Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity) | |
| Cellular Location Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus | |
DAX1 (NR0B1) Antibody (C-term) - Related products
AP2708a: DAX1 (NR0B1) Antibody (N-term)
AP2708b: DAX1 (NR0B1) Antibody (C-term)
RI13660: NR0B1 predesign siRNA
BP2708a: NROB1 Antibody (N-term) Blocking Peptide
DAX1 (NR0B1) Antibody (C-term) - Application data
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Western blot analysis of NROB1 (arrow) using rabbit polyclonal NROB1 Antibody (Human C-term) (Cat.#AP2708b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NROB1 gene (Lane 2) (Origene Technologies).
DAX1 (NR0B1) Antibody (C-term) - Research Areas
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BACKGROUND
NROB1contains a DNA-binding domain and acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in the NROB1 gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
REFERENCES
Calliari,L.E., Genet. Mol. Res. 6 (2), 177-183 (2007) Kinsey,M., Mol. Cancer Res. 4 (11), 851-859 (2006)
