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M Sema5a Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - M Sema5a  Antibody (N-term) AP2712a
    Anti-M Sema5a Antibody (N-term) at 1:1000 dilution + Mouse liver tissue lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 121 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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  • SPECIFICATION
  • CITATIONS: 1
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q13591
Other Accession D3ZTD8, Q62217
Reactivity Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 120615 Da
Additional Information
Gene ID 9037
Other Names Semaphorin-5A, Semaphorin-F, Sema F, SEMA5A, SEMAF
Target/Specificity This Mouse Sema5a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of mouse Sema5a.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsM Sema5a Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SEMA5A
Synonyms SEMAF
Function Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
Cellular Location Membrane; Single-pass type I membrane protein.
Research Areas
Citations ( 0 )

Background

Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development.

References

Bialecka,M., Neurosci. Lett. 399 (1-2), 121-123 (2006)
Melin,M., Neuropsychobiology 54 (1), 64-69 (2006)

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$ 365.00
$ 140.00
Cat# AP2712a
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