|Application ||WB, IHC-P, E|
|Other Accession||Q3UTH8, O43307, Q58DL7|
|Calculated MW||58157 Da|
|Antigen Region||274-303 aa|
|Other Names||Rho guanine nucleotide exchange factor 9, Collybistin, Rac/Cdc42 guanine nucleotide exchange factor 9, Arhgef9|
|Target/Specificity||This Arhgef9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-303 amino acids from the Central region of human Arhgef9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Arhgef9 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.|
|Tissue Location||Detected in brain, throughout the gray matter. Detected at low levels in heart and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.
Xiang,S., J. Mol. Biol. 359 (1), 35-46 (2006)
Harvey,K., J. Neurosci. 24 (25), 5816-5826 (2004)
Grosskreutz,Y., Biol. Chem. 382 (10), 1455-1462 (2001)
Kins,S., Nat. Neurosci. 3 (1), 22-29 (2000)
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