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S adenosylhomocysteine hydrolase (ACHY) Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - S adenosylhomocysteine hydrolase (ACHY) Antibody (N-term) AP2733a
    Western blot analysis of anti-AHCY Pab (Cat.#AP2733a) in 293 cell line lysates (35ug/lane).AHCY (arrow) was detected using the purified Pab.
    detail
  • IHC-P - S adenosylhomocysteine hydrolase (ACHY) Antibody (N-term) AP2733a
    Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with AHCY antibody (N-term) (Cat.#AP2733a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P23526
Other Accession Q710C4, Q4R596, Q3MHL4
Reactivity Human
Predicted Bovine, Monkey, Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 47716 Da
Antigen Region 79-110 aa
Additional Information
Gene ID 191
Other Names Adenosylhomocysteinase, AdoHcyase, S-adenosyl-L-homocysteine hydrolase, AHCY, SAHH
Target/Specificity This S adenosylhomocysteine hydrolase (ACHY) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-110 amino acids from the N-terminal region of human S adenosylhomocysteine hydrolase (ACHY).
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsS adenosylhomocysteine hydrolase (ACHY) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AHCY
Synonyms SAHH
Function Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:10933798). Binds copper ions (By similarity).
Cellular Location Cytoplasm. Melanosome. Nucleus. Endoplasmic reticulum. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Research Areas
Citations (0)
citation

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Background

S-adenosylhomocysteine hydrolase (AHCY) catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family.

References

Yideng,J.,DNA Cell Biol. 26 (8), 603-611 (2007)
Arredondo-Vega,F.X.,Ann. Hum. Genet. 53 (PT 2), 157-167 (1989)
Li,Q.S.,Biochemistry 47 (17), 4983-4991 (2008)

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$ 365.00
$ 140.00
Cat# AP2733a
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