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AKR1A1 Antibody (N-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP2734a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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AKR1A1 Antibody (N-term) - Product info | |
| Application | WB, IHC
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| Primary Accession | P14550 |
| Other Accession | Q6IAZ4 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 36573 Da |
AKR1A1 Antibody (N-term) - Additional info | |
| Gene ID 10327 | |
| Other Names AKR1A1; ALDR1; ALR; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Aldo-keto reductase family 1 member A1 | |
| Target/Specificity This AKR1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46~75 amino acids from the N-terminal region of human AKR1A1. | |
| Dilution WB~~1:50~100WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AKR1A1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AKR1A1 Antibody (N-term) - Protein Information | |
| Name AKR1A1 | |
| Synonyms ALDR1, ALR | |
| Function Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) | |
| Tissue Location Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung | |
AKR1A1 Antibody (N-term) - Related products
AP2734a: AKR1A1 Antibody (N-term)
AP2734b: AKR1A1 Antibody (C-term)
RI10207: AKR1A1 predesign siRNA
DC00324: Human AKR1A1 cDNA Clone
LY10801a: AKR1A1 Over-expression Lysate
BP2734a: AKR1A1 Antibody (N-term) Blocking Peptide
AKR1A1 Antibody (N-term) - Application data
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Western blot analysis of anti-AKR1A1 Pab (Cat.#AP2734a) in Jurkat cell line lysates (35ug/lane).AKR1A1 (arrow) was detected using the purified Pab (1:60 dilution).
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Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with AKR1A1 antibody (N-term) (Cat.#AP2734a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Western blot analysis of AKR1A1 (arrow) using rabbit polyclonal AKR1A1 Antibody (N-term) (Cat.#AP2734a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the AKR1A1 gene.
AKR1A1 Antibody (N-term) - Research Areas
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BACKGROUND
AKR1A1 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue.
REFERENCES
Steuber,H.,J. Mol. Biol. 379 (5), 991-1016 (2008) Bohren,K.M.,Biochim. Biophys. Acta 1748 (2), 201-212 (2005) El-Kabbani,O.,Acta Crystallogr. D Biol. Crystallogr. 50 (PT 6), 859-868 (1994)
