|Application ||WB, IHC-P, E|
|Calculated MW||114395 Da|
|Antigen Region||998-1028 aa|
|Other Names||Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, SEMA6A, KIAA1368, SEMAQ|
|Target/Specificity||This SEMA6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 998-1028 amino acids from the C-terminal region of human SEMA6A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEMA6A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
SEMA6A can act as repulsive axon guidance cues. It may play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.
Prislei,S., Mol. Cancer Ther. 7 (1), 233-241 (2008)
Katoh,M., Int. J. Mol. Med. 20 (3), 405-409 (2007)
Gautier,G., Am. J. Pathol. 168 (2), 453-465 (2006)
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