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LGR5 (GPR49) Antibody (loop1)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP2745c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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LGR5 (GPR49) Antibody (loop1) - Product info | |
| Application | IHC, WB
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| Primary Accession | O75473 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 99998 Da |
LGR5 (GPR49) Antibody (loop1) - Additional info | |
| Gene ID 8549 | |
| Other Names LGR5; GPR49; GPR67; Leucine-rich repeat-containing G-protein coupled receptor 5; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38 | |
| Target/Specificity This LGR5 (GPR49) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 614~644 amino acids from the loop1 region of human LGR5. | |
| Dilution IHC~~1:10~50 WB~~1:50~100WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions LGR5 (GPR49) Antibody (loop1) is for research use only and not for use in diagnostic or therapeutic procedures. | |
LGR5 (GPR49) Antibody (loop1) - Protein Information | |
| Name LGR5 | |
| Synonyms GPR49, GPR67 | |
| Function Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling | |
| Cellular Location Cell membrane; Multi-pass membrane protein. | |
| Tissue Location Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver | |
LGR5 (GPR49) Antibody (loop1) - Related products
AP2745a: LGR5/GPR49 Antibody (N-term)
AP2745c: LGR5 (GPR49) Antibody (loop1)
AP2745d: LGR5 Antibody (loop2)
AP2745f: LGR5 (GPR49) Antibody (Center)
BP2745d: LGR5/GPR49 Antibody (loop2) Blocking Peptide
LGR5 (GPR49) Antibody (loop1) - Application data
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Formalin-fixed and paraffin-embedded human brain tissue reacted with LGR5/GPR49 antibody (loop1) (Cat.#AP2745c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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LGR5/GPR49 Antibody (loop1) (Cat. #AP11867a) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the LGR5/GPR49 antibody detected the LGR5/GPR49 protein (arrow).
LGR5 (GPR49) Antibody (loop1) - Research Areas
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BACKGROUND
LGR5/GPR49 is an orphan receptor. It may be an important receptor for signals controlling growth and differentiation of specific embryonic tissues.
REFERENCES
Barker,N., Nature 449 (7165), 1003-1007 (2007) McClanahan,T., Cancer Biol. Ther. 5 (4), 419-426 (2006) Yamamoto,Y., Hepatology 37 (3), 528-533 (2003) Hsu,S.Y., Mol. Endocrinol. 14 (8), 1257-1271 (2000)
