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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   OPRS1 Antibody (Center)   

OPRS1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - OPRS1 Antibody (Center) AP2747c
    Western blot analysis of OPRS1 (arrow) using rabbit polyclonal OPRS1 Antibody (Center) (Cat.#AP2747c).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the OPRS1 gene (Lane 2) (Origene Technologies).
  • WB - OPRS1 Antibody (Center) AP2747c
    OPRS1 Antibody (Center) (Cat.#AP2747c) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the OPRS1 antibody detected the OPRS1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99720
Other Accession Q58DH7
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 25128 Da
Antigen Region 118-147 aa
Additional Information
Gene ID 10280
Other Names Sigma non-opioid intracellular receptor 1, Aging-associated gene 8 protein, SR31747-binding protein, SR-BP, Sigma 1-type opioid receptor, SIG-1R, Sigma1-receptor, Sigma1R, hSigmaR1, SIGMAR1, OPRS1, SRBP
Target/Specificity This OPRS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-147 amino acids from the Central region of human OPRS1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsOPRS1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms OPRS1, SRBP
Function Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.
Cellular Location Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection, growth cone Note=Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand- binding
Tissue Location Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells.
Research Areas
Citations (0)

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OPRS1 is a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems.


Cobos,E.J.,J. Neurochem. 102 (3), 812-825 (2007)
Maurice,T., Pharmacol. Biochem. Behav. 84 (4), 581-597 (2006)
Lee,I.T.,Eur. J. Pharmacol. 578 (2-3), 123-136 (2008)

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$ 295.00
$ 99.00
Cat# AP2747c
(40 western blots)
Availability: In Stock
Bulk Size
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