|Application ||WB, E|
|Calculated MW||17599 Da|
|Antigen Region||40-71 aa|
|Other Names||Microsomal glutathione S-transferase 1, Microsomal GST-1, Microsomal GST-I, MGST1, GST12, MGST|
|Target/Specificity||This MGST1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-71 amino acids from the Central region of human MGST1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MGST1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.|
|Cellular Location||Microsome. Mitochondrion outer membrane; Peripheral membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in liver.|
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Provided below are standard protocols that you may find useful for product applications.
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds.This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress.
Zhang,H., Int J Colorectal Dis 22 (10), 1185-1194 (2007)
Prall,W.C., Mech. Ageing Dev. 128 (9), 503-510 (2007)
Haines,J.L.,Invest. Ophthalmol. Vis. Sci. 47 (1), 329-335 (2006)
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