|Application ||WB, E|
|Calculated MW||53944 Da|
|Antigen Region||200-228 aa|
|Other Names||Monocarboxylate transporter 1, MCT 1, Solute carrier family 16 member 1, SLC16A1, MCT1|
|Target/Specificity||This MCT1 (SLC16A1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-228 amino acids from the Central region of human MCT1 (SLC16A1).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MCT1 (SLC16A1) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.|
|Cellular Location||Cell membrane; Multi- pass membrane protein|
|Tissue Location||Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed|
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Provided below are standard protocols that you may find useful for product applications.
SLC16A1 is a monocarboxylate transporter (MCT1) that mediates the movement of lactate and pyruvate across cell membranes. Import and export of these substrates by tissues such as erythrocytes, muscle, intestine, and kidney are ascribed largely to the action of a proton-coupled MCT (Garcia et al., 1994 [PubMed 8124722]).
Pinheiro,C., Virchows Arch. 452 (2), 139-146 (2008)
Otonkoski,T., Am. J. Hum. Genet. 81 (3), 467-474 (2007)
Martin-Venegas,R., J. Nutr. 137 (1), 49-54 (2007)
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