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MCT1 (SLC16A1) Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MCT1 (SLC16A1) Antibody (Center) AP2753c
    Western blot analysis of anti-SLC16A1 Antibody (Center) (Cat.#AP2753c) in CEM cell line lysates (35ug/lane).SLC16A1 (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P53985
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 53944 Da
Antigen Region 200-228 aa
Additional Information
Gene ID 6566
Other Names Monocarboxylate transporter 1, MCT 1, Solute carrier family 16 member 1, SLC16A1, MCT1
Target/Specificity This MCT1 (SLC16A1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-228 amino acids from the Central region of human MCT1 (SLC16A1).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMCT1 (SLC16A1) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC16A1
Synonyms MCT1
Function Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.
Cellular Location Cell membrane; Multi- pass membrane protein
Tissue Location Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed
Research Areas
Citations (0)

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SLC16A1 is a monocarboxylate transporter (MCT1) that mediates the movement of lactate and pyruvate across cell membranes. Import and export of these substrates by tissues such as erythrocytes, muscle, intestine, and kidney are ascribed largely to the action of a proton-coupled MCT (Garcia et al., 1994 [PubMed 8124722]).


Pinheiro,C., Virchows Arch. 452 (2), 139-146 (2008)
Otonkoski,T., Am. J. Hum. Genet. 81 (3), 467-474 (2007)
Martin-Venegas,R., J. Nutr. 137 (1), 49-54 (2007)

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Cat# AP2753c
(40 western blots)
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