|Application ||WB, IHC-P, FC, E|
|Calculated MW||50569 Da|
|Antigen Region||239-267 aa|
|Other Names||Zinc finger protein ZIC 3, Zinc finger protein 203, Zinc finger protein of the cerebellum 3, ZIC3, ZNF203|
|Target/Specificity||This ZIC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-267 amino acids from the Central region of human ZIC3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZIC3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.|
|Cellular Location||Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs.
Hatayama, M., et al. Hum. Mol. Genet. 17(22):3459-3473(2008)
Zhu, L., et al. Hum. Mutat. 29(1):99-105(2008)
Zhu, L., et al. Hum. Mol. Genet. 16(14):1649-1660(2007)
Chhin, B., et al. Hum. Mutat. 28(6):563-570(2007)
Bedard, J.E., et al. Hum. Mol. Genet. 16(2):187-198(2007)
Zhu, H., et al. Am. J. Med. Genet. A 116A (4), 414-415 (2003) :
Koyabu, Y., et al. J. Biol. Chem. 276(10):6889-6892(2001)
Klootwijk, R., et al. Hum. Mol. Genet. 9(11):1615-1622(2000)
Gebbia, M., et al. Nat. Genet. 17(3):305-308(1997)
Casey, B., et al. Nat. Genet. 5(4):403-407(1993)
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