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ZIC3 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ZIC3 Antibody (Center) AP2761c
    Anti-ZIC3 Antibody (Center) at 1:1000 dilution + HL-60 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 51 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - ZIC3 Antibody (Center) AP2761c
    ZIC3 Antibody (Center) (Cat. #AP2761c) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ZIC3 antibody detected the ZIC3 protein (arrow).
  • IHC-P - ZIC3 Antibody (Center) AP2761c
    ZIC3 Antibody (Center) (Cat. #AP2761c) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ZIC3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - ZIC3 Antibody (Center) AP2761c
    ZIC3 Antibody (Center) (Cat. #AP2761c) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60481
Other Accession NP_003404.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 50569 Da
Antigen Region 239-267 aa
Additional Information
Gene ID 7547
Other Names Zinc finger protein ZIC 3, Zinc finger protein 203, Zinc finger protein of the cerebellum 3, ZIC3, ZNF203
Target/Specificity This ZIC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-267 amino acids from the Central region of human ZIC3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZIC3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZIC3
Synonyms ZNF203
Function Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
Cellular Location Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6.
Research Areas
Citations (0)

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This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs.


Hatayama, M., et al. Hum. Mol. Genet. 17(22):3459-3473(2008)
Zhu, L., et al. Hum. Mutat. 29(1):99-105(2008)
Zhu, L., et al. Hum. Mol. Genet. 16(14):1649-1660(2007)
Chhin, B., et al. Hum. Mutat. 28(6):563-570(2007)
Bedard, J.E., et al. Hum. Mol. Genet. 16(2):187-198(2007)
Zhu, H., et al. Am. J. Med. Genet. A 116A (4), 414-415 (2003) :
Koyabu, Y., et al. J. Biol. Chem. 276(10):6889-6892(2001)
Klootwijk, R., et al. Hum. Mol. Genet. 9(11):1615-1622(2000)
Gebbia, M., et al. Nat. Genet. 17(3):305-308(1997)
Casey, B., et al. Nat. Genet. 5(4):403-407(1993)

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$ 295.00
$ 99.00
Cat# AP2761c
(40 western blots)
Availability: In Stock
Bulk Size
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