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MCAM Antibody (Y641)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP2767a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
MCAM Antibody (Y641) - Product info | |
| Application | WB
|
| Primary Accession | P43121 |
| Other Accession | Q9EPF2, Q8R2Y2, NP_006491 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 71607 Da |
MCAM Antibody (Y641) - Additional info | |
| Gene ID 4162 | |
| Other Names MCAM; MUC18; Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD_antigen=CD146; Flags: Precursor | |
| Target/Specificity This MCAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 617~646 amino acids surrounding Y641 of human MCAM. | |
| Dilution WB~~1:50~100WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions MCAM Antibody (Y641) is for research use only and not for use in diagnostic or therapeutic procedures. | |
MCAM Antibody (Y641) - Protein Information | |
| Name MCAM | |
| Synonyms MUC18 | |
| Function Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration | |
| Cellular Location Membrane; Single-pass type I membrane protein | |
| Tissue Location Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis | |
MCAM Antibody (Y641) - Related products
AP2767b: MCAM Antibody (C-term)
AP2767C: MCAM Antibody (Center)
AP3572a: Phospho-MCAM-pY641 Antibody
DC08049: Human MCAM cDNA Clone
BP2767a: MCAM Antibody (Y641) Blocking Peptide
BP2767b: MCAM Antibody (C-term) Blocking Peptide
BP2767C: MCAM Antibody (Center) Blocking Peptide
MCAM Antibody (Y641) - Application data
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Western blot analysis of anti-MCAM Antibody (Y641) (Cat.#AP2767a) in A375 cell line lysates (35ug/lane). MCAM (arrow) was detected using the purified Pab.
MCAM Antibody (Y641) - Research Areas
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BACKGROUND
MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. It could be an adhesion molecule active in neural crest cells during embryonic development. It acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
REFERENCES
Fritzsche,F.R., Pathology 40 (5), 457-464 (2008) Malyszko,J., Clin. Appl. Thromb. Hemost. 14 (3), 338-345 (2008) Guezguez,B., J. Immunol. 179 (10), 6673-6685 (2007)
