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B2M Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - B2M Antibody (C-term) AP2771b
    B2M Antibody (C-term) (Cat. #AP2771b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the B2M antibody detected the B2M protein (arrow).
    detail
  • IHC-P - B2M Antibody (C-term) AP2771b
    Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with B2M antibody (C-term) (Cat.#AP2771b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
  • FC - B2M Antibody (C-term) AP2771b
    B2M Antibody (C-term) (Cat. #AP2771b) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
  • SPECIFICATION
  • CITATIONS: 1
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession P61769
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 13715 Da
Antigen Region 86-118 aa
Additional Information
Gene ID 567
Other Names Beta-2-microglobulin, Beta-2-microglobulin form pI 53, B2M
Target/Specificity This B2M antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-118 amino acids from the C-terminal region of human B2M.
Dilution WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsB2M Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name B2M (HGNC:914)
Function Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
Cellular Location Secreted. Cell surface. Note=Detected in serum and urine (PubMed:1336137, PubMed:7554280). {ECO:0000269|PubMed:7554280, ECO:0000269|Ref.6}
Research Areas
Citations ( 0 )

Background

Beta-2-microglobulin is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells.

References

Sakata,M., J. Mol. Biol. 382 (5), 1242-1255 (2008)
Huang,W.C., Clin. Cancer Res. 14 (17), 5341-5347 (2008)
Gattoni-Celli,S., Cancer Res. 52 (5), 1201-1204 (1992)

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$ 365.00
$ 140.00
Cat# AP2771b
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