|Application ||WB, IHC-P, IF, FC, E|
|Other Accession||P22449, P49698|
|Calculated MW||52785 Da|
|Antigen Region||281-312 aa|
|Other Names||Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, Nuclear receptor subfamily 2 group A member 1, Transcription factor 14, TCF-14, Transcription factor HNF-4, HNF4A, HNF4, NR2A1, TCF14|
|Target/Specificity||This HNF4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-312 amino acids from the Central region of human HNF4A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HNF4A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HNF4, NR2A1, TCF14|
|Function||Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1- alpha. May be essential for development of the liver, kidney and intestine.|
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Provided below are standard protocols that you may find useful for product applications.
HNF4A is a nuclear transcription factor which binds DNA as a homodimer. This protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This protein may play a role in development of the liver, kidney, and intestines. Mutations in HNF4A gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I.
Kritis A.A., Argyrokastritis A.Gene 173:275-280(1996)
Yamagata K., Furuta H., Oda N.Nature 384:458-460(1996)
Furuta H., Iwasaki N., Oda N.Diabetes 46:1652-1657(1997)
Moeller A.M., Urhammer S.A.Diabetologia 40:980-983(1997)
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