HNF4A Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC-P, IF, FC, E |
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Primary Accession | P41235 |
Other Accession | P22449, P49698 |
Reactivity | Human, Rat |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit Ig |
Calculated MW | 52785 Da |
Antigen Region | 281-312 aa |
Gene ID | 3172 |
---|---|
Other Names | Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, Nuclear receptor subfamily 2 group A member 1, Transcription factor 14, TCF-14, Transcription factor HNF-4, HNF4A, HNF4, NR2A1, TCF14 |
Target/Specificity | This HNF4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-312 amino acids from the Central region of human HNF4A. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 IF~~1:10~50 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | HNF4A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HNF4A |
---|---|
Synonyms | HNF4, NR2A1, TCF14 |
Function | Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1- alpha. May be essential for development of the liver, kidney and intestine. |
Cellular Location | Nucleus. |

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Provided below are standard protocols that you may find useful for product applications.
Background
HNF4A is a nuclear transcription factor which binds DNA as a homodimer. This protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This protein may play a role in development of the liver, kidney, and intestines. Mutations in HNF4A gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I.
References
Kritis A.A., Argyrokastritis A.Gene 173:275-280(1996)
Yamagata K., Furuta H., Oda N.Nature 384:458-460(1996)
Furuta H., Iwasaki N., Oda N.Diabetes 46:1652-1657(1997)
Moeller A.M., Urhammer S.A.Diabetologia 40:980-983(1997)

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