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AASS Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - AASS Antibody (Center) AP2779C
    Western blot analysis of AASS Antibody (Center) (Cat. #AP2779c) in 293 cell line lysates (35ug/lane). AASS (arrow) was detected using the purified Pab.
  • IHC-P - AASS Antibody (Center) AP2779C
    Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with the AASS antibody (Center) (Cat.#AP2779c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • WB - AASS Antibody (Center) AP2779C
    AASS Antibody (Center) (Cat.#AP2779c) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the AASS antibody detected the AASS protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UDR5
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 102132 Da
Antigen Region 264-294 aa
Additional Information
Gene ID 10157
Other Names Alpha-aminoadipic semialdehyde synthase, mitochondrial, LKR/SDH, Lysine ketoglutarate reductase, LKR, LOR, Saccharopine dehydrogenase, SDH, AASS
Target/Specificity This AASS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-294 amino acids from the Central region of human AASS.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAASS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.
Cellular Location Mitochondrion.
Tissue Location Expressed in all 16 tissues examined with highest expression in the liver
Research Areas
Citations (0)

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AASS is a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in the gene encoding this protein are associated with familial hyperlysinemia.


Sacksteder,K.A., Am. J. Hum. Genet. 66 (6), 1736-1743 (2000)

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Cat# AP2779C
(40 western blots)
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