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GADD45A Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GADD45A Antibody (N-term) AP2785A
    Western blot analysis of anti-GADD45A Antibody (N-term) (Cat.#AP2785a) in Y79 cell line lysates (35ug/lane). GADD45A (arrow) was detected using the purified Pab.
  • WB - GADD45A Antibody (N-term) AP2785A
    Western blot analysis of GADD45A (arrow) using rabbit polyclonal GADD45A Antibody (N-term) (Cat.#AP2785a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GADD45A gene.
  • FC - GADD45A Antibody (N-term) AP2785A
    GADD45A Antibody (N-term) (Cat. #AP2785a) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P24522
Other Accession Q3ZBN6
Reactivity Human
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 18336 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 1647
Other Names Growth arrest and DNA damage-inducible protein GADD45 alpha, DNA damage-inducible transcript 1 protein, DDIT-1, GADD45A, DDIT1, GADD45
Target/Specificity This GADD45A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GADD45A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGADD45A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GADD45A
Synonyms DDIT1, GADD45
Function In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.
Cellular Location Nucleus.
Citations (0)

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GADD45A responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45A gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.


Li,L.S., J. Biol. Chem. 283 (31), 21394-21403 (2008) Al-Romaih,K., Neoplasia 10 (5), 471-480 (2008) Zhu,Q.S., Cancer Res. 68 (8), 2895-2903 (2008) Kearsey,J.M., Oncogene 11 (9), 1675-1683 (1995)

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Cat# AP2785A
(40 western blots)
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