|Application ||WB, E|
|Calculated MW||62412 Da|
|Antigen Region||395-422 aa|
|Other Names||Glypican-4, K-glypican, Secreted glypican-4, GPC4|
|Target/Specificity||This GPC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-422 amino acids from the Central region of human GPC4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPC4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side|
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Provided below are standard protocols that you may find useful for product applications.
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.
Karumanchi,S.A., Mol. Cell 7 (4), 811-822 (2001)
Hagihara,K., Dev. Dyn. 219 (3), 353-367 (2000)
Veugelers,M., Hum. Mol. Genet. 9 (9), 1321-1328 (2000)
Veugelers,M., Genomics 53 (1), 1-11 (1998)
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