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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   M6PR Antibody (N-term)   

M6PR Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - M6PR Antibody (N-term) AP2792a
    Western blot analysis of M6PR Antibody (N-term)(Cat. #AP2792a) in mouse brain tissue lysates (35ug/lane). M6PR (arrow) was detected using the purified Pab.
  • IHC-P - M6PR Antibody (N-term) AP2792a
    Formalin-fixed and paraffin-embedded human testis tissue reacted with M6PR antibody (N-term) (Cat.#AP2792a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P20645
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 30993 Da
Antigen Region 35-63 aa
Additional Information
Gene ID 4074
Other Names Cation-dependent mannose-6-phosphate receptor, CD Man-6-P receptor, CD-MPR, 46 kDa mannose 6-phosphate receptor, MPR 46, M6PR, MPR46, MPRD
Target/Specificity This M6PR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-63 amino acids from the N-terminal region of human M6PR.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsM6PR Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name M6PR
Synonyms MPR46, MPRD
Function Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Cellular Location Lysosome membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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M6PR is a receptor for mannose-6-phosphate groups on lysosomal enzymes. The receptor forms a homodimer or homotetramer for intracellular targeting of lysosomal enzymes and export of newly synthesized lysosomal enzymes into the cell secretions. The receptor is an integral membrane protein which localizes to the trans-Golgi reticulum, endosomes, and the plasma membrane.


Perez-Victoria,F.J., Mol. Biol. Cell 19 (6), 2350-2362 (2008)
Mari,M., Traffic 9 (3), 380-393 (2008)
Lemansky,P., J. Leukoc. Biol. 81 (4), 1149-1158 (2007)
Chen,J.J., Cell 119 (7), 915-926 (2004)

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$ 295.00
$ 99.00
Cat# AP2792a
(40 western blots)
Availability: In Stock
Bulk Size
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