|Application ||WB, IHC-P, E|
|Calculated MW||30993 Da|
|Antigen Region||35-63 aa|
|Other Names||Cation-dependent mannose-6-phosphate receptor, CD Man-6-P receptor, CD-MPR, 46 kDa mannose 6-phosphate receptor, MPR 46, M6PR, MPR46, MPRD|
|Target/Specificity||This M6PR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-63 amino acids from the N-terminal region of human M6PR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||M6PR Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.|
|Cellular Location||Lysosome membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
M6PR is a receptor for mannose-6-phosphate groups on lysosomal enzymes. The receptor forms a homodimer or homotetramer for intracellular targeting of lysosomal enzymes and export of newly synthesized lysosomal enzymes into the cell secretions. The receptor is an integral membrane protein which localizes to the trans-Golgi reticulum, endosomes, and the plasma membrane.
Perez-Victoria,F.J., Mol. Biol. Cell 19 (6), 2350-2362 (2008)
Mari,M., Traffic 9 (3), 380-393 (2008)
Lemansky,P., J. Leukoc. Biol. 81 (4), 1149-1158 (2007)
Chen,J.J., Cell 119 (7), 915-926 (2004)
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