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ATXN1 Antibody (S776)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ATXN1 Antibody (S776) AP2808A
    Anti-ATXN1 Antibody (S776) at 1:2000 dilution + HT-29 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size :87kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • IF - ATXN1 Antibody (S776) AP2808A
    Confocal immunofluorescent analysis of ATXN1 Antibody (S776)(Cat#AP2808a) with hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P54253
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 86923 Da
Antigen Region 754-781 aa
Additional Information
Gene ID 6310
Other Names Ataxin-1, Spinocerebellar ataxia type 1 protein, ATXN1, ATX1, SCA1
Target/Specificity This ATXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 754-781 amino acids from human ATXN1.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsATXN1 Antibody (S776) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATXN1
Synonyms ATX1, SCA1
Function Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.
Cellular Location Cytoplasm. Nucleus. Note=Colocalizes with USP7 in the nucleus
Tissue Location Widely expressed throughout the body.
Research Areas
Citations (0)

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The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known.


Hong,S., Biochem. Biophys. Res. Commun. 371 (2), 256-260 (2008)
Lim,J., Nature 452 (7188), 713-718 (2008)
Krol,H.A., PLoS ONE 3 (1), E1503 (2008)

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$ 295.00
$ 99.00
Cat# AP2808A
(40 western blots)
Availability: In Stock
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