WDYHV1 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
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Primary Accession | Q96HA8 |
Other Accession | Q3T0D3 |
Reactivity | Human, Mouse |
Predicted | Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 23680 Da |
Antigen Region | 106-136 aa |
Gene ID | 55093 |
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Other Names | Protein N-terminal glutamine amidohydrolase, 351-, Protein NH2-terminal glutamine deamidase, N-terminal Gln amidase, Nt(Q)-amidase, WDYHV motif-containing protein 1, WDYHV1, C8orf32, NTAQ1 |
Target/Specificity | This WDYHV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-136 amino acids from the Central region of human WDYHV1. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | WDYHV1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NTAQ1 (HGNC:25490) |
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Synonyms | C8orf32, WDYHV1 |
Function | Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine. |
Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q80WB5}. Nucleus {ECO:0000250|UniProtKB:Q80WB5} |
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Provided below are standard protocols that you may find useful for product applications.
References
Lim,J., Cell 125 (4), 801-814 (2006)
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