|Application ||WB, IHC-P, FC, E|
|Other Accession||Q9XS97, Q9WU12, Q9XS96|
|Predicted||Mouse, Rabbit, Bovine|
|Calculated MW||8412 Da|
|Antigen Region||4-32 aa|
|Other Names||SNRPN upstream reading frame protein, SNURF|
|Target/Specificity||This SNURF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the Central region of human SNURF.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SNURF Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed in heart, skeletal muscle and lymphoblasts (at protein level). Expressed in brain, pancreas, heart, liver, lung, kidney and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
SNURF is a highly basic protein localized to the nucleus. The evolutionarily constrained open reading frame of its gene is found on a bicistronic transcript which has a downstream ORF encoding the small nuclear ribonucleoprotein polypeptide N. The upstream coding region utilizes the first three exons of the transcript, a region that has been identified as an imprinting center. Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region but the full-length nature of these transcripts has not been determined. An alternate exon has been identified that substitutes for exon 4 and leads to a truncated, monocistronic transcript. Alternative splicing or deletion caused by a translocation event in the 5' UTR or coding region of this gene leads to Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. The function of this protein is not yet known.
Rodriguez-Jato,S., Nucleic Acids Res. 33 (15), 4740-4753 (2005)
Runte,M., Hum. Genet. 114 (6), 553-561 (2004)
Runte,M., Hum. Mol. Genet. 10 (23), 2687-2700 (2001)
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