- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Other Accession||Q91VC0, Q9QY93|
|Calculated MW||18681 Da|
|Antigen Region||12-40 aa|
|Other Names||dCTP pyrophosphatase 1, Deoxycytidine-triphosphatase 1, dCTPase 1, RS21C6, XTP3-transactivated gene A protein, DCTPP1, XTP3TPA|
|Target/Specificity||This XTP3TPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human XTP3TPA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||XTP3TPA Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non- canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity).|
Provided below are standard protocols that you may find useful for product applications.
Stelzl,U., Cell 122 (6), 957-968 (2005)
Moroz,O.V., J. Mol. Biol. 347 (2), 243-255 (2005)
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