|Application ||WB, IHC-P, E|
|Calculated MW||54911 Da|
|Antigen Region||205-234 aa|
|Other Names||DNA polymerase subunit gamma-2, mitochondrial, DNA polymerase gamma accessory 55 kDa subunit, p55, Mitochondrial DNA polymerase accessory subunit, MtPolB, PolG-beta, POLG2, MTPOLB|
|Target/Specificity||This POLG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the Central region of human POLG2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||POLG2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.|
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Provided below are standard protocols that you may find useful for product applications.
The accuracy of mitochondrial DNA (mtDNA) replication depends on the coordinated action of many nuclear-encoded proteins and on the correct balance of nucleotides within the mitochondrial matrix. mtDNA is replicated by DNA polymerase gamma, which is composed of a 140-kD catalytic subunit(POLG1) and a 55-kD accessory subunit (POLG2).
Longley,M.J., Am. J. Hum. Genet. 78 (6), 1026-1034 (2006)
Carrodeguas,J.A., J. Biol. Chem. 277 (51), 50008-50014 (2002)
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