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SNRPC Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SNRPC Antibody (C-term) AP2841b
    Western blot analysis of anti-SNRPC Antibody (C-term) (Cat.#AP2841b) in K562 cell line lysates (35ug/lane). SNRPC(arrow) was detected using the purified Pab.
    detail
  • IHC-P - SNRPC Antibody (C-term) AP2841b
    Formalin-fixed and paraffin-embedded human brain tissue reacted with SNRPC Antibody (C-term) (Cat.#AP2841b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
  • FC - SNRPC Antibody (C-term) AP2841b
    SNRPC Antibody (C-term) (Cat. #AP2841b) flow cytometry analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, IHC-P, WB, E
Primary Accession P09234
Other Accession D3ZCL3, Q62241, E1C6F0, Q32PA0
Reactivity Human
Predicted Bovine, Chicken, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 17394 Da
Antigen Region 133-159 aa
Additional Information
Gene ID 6631
Other Names U1 small nuclear ribonucleoprotein C {ECO:0000255|HAMAP-Rule:MF_03153}, U1 snRNP C {ECO:0000255|HAMAP-Rule:MF_03153}, U1-C {ECO:0000255|HAMAP-Rule:MF_03153}, U1C {ECO:0000255|HAMAP-Rule:MF_03153}, SNRPC {ECO:0000255|HAMAP-Rule:MF_03153}
Target/Specificity This SNRPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-159 amino acids from the C-terminal region of human SNRPC.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSNRPC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNRPC {ECO:0000255|HAMAP-Rule:MF_03153}
Function Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Cellular Location Nucleus {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:2136774}
Research Areas
Citations (0)
citation

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Background

SNRPC is associated with snRNP U1.

References

Hochleitner,E.O., J. Biol. Chem. 280 (4), 2536-2542 (2005)
Muto,Y., J. Mol. Biol. 341 (1), 185-198 (2004)
Forch,P., EMBO J. 21 (24), 6882-6892 (2002)
Gunnewiek,J.M., Nucleic Acids Res. 23 (23), 4864-4871 (1995)

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$ 365.00
$ 140.00
Cat# AP2841b
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