|Application ||IF, WB, IHC-P, E|
|Calculated MW||69285 Da|
|Antigen Region||163-191 aa|
|Other Names||Leukotriene A-4 hydrolase, LTA-4 hydrolase, Leukotriene A(4) hydrolase, LTA4H, LTA4|
|Target/Specificity||This LTA4H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-191 amino acids from the Central region of human LTA4H.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LTA4H Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.|
|Tissue Location||Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts|
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Provided below are standard protocols that you may find useful for product applications.
DHCR24 hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). This enzyme also has some peptidase activity.
Bevan,S., Stroke 40 (3), 696-701 (2009) Crosslin,D.R., Hum. Genet. 125 (2), 217-229 (2009) Huston,A.L., Biochim. Biophys. Acta 1784 (11), 1865-1872 (2008) Rybina,I.V., J. Biol. Chem. 272 (50), 31865-31871 (1997)
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