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LTA4H Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • IF - LTA4H Antibody (Center) AP2844c
    Confocal immunofluorescent analysis of LTA4H Antibody (Center)(Cat#AP2844c) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
    detail
  • WB - LTA4H Antibody (Center) AP2844c
    Western blot analysis of LTA4H Antibody (Center) (Cat. #AP2844c) in T47D cell line lysates (35ug/lane). LTA4H (arrow) was detected using the purified Pab.
    detail
  • IHC-P - LTA4H Antibody (Center) AP2844c
    Formalin-fixed and paraffin-embedded human lymph tissue reacted with LTA4H Antibody (Center) (Cat. #AP2844c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P09960
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 69285 Da
Antigen Region 163-191 aa
Additional Information
Gene ID 4048
Other Names Leukotriene A-4 hydrolase, LTA-4 hydrolase, Leukotriene A(4) hydrolase, LTA4H, LTA4
Target/Specificity This LTA4H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-191 amino acids from the Central region of human LTA4H.
Dilution IF~~1:10~50
WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLTA4H Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LTA4H
Synonyms LTA4
Function Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:20813919, PubMed:18804029). In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti- inflammatory and pro-resolving actions (PubMed:21206090).
Cellular Location Cytoplasm.
Tissue Location Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts
Research Areas
Citations (0)
citation

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Background

DHCR24 hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). This enzyme also has some peptidase activity.

References

Bevan,S., Stroke 40 (3), 696-701 (2009) Crosslin,D.R., Hum. Genet. 125 (2), 217-229 (2009) Huston,A.L., Biochim. Biophys. Acta 1784 (11), 1865-1872 (2008) Rybina,I.V., J. Biol. Chem. 272 (50), 31865-31871 (1997)

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$ 182.50
$ 70.00
Cat# AP2844c
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