|Application ||WB, E|
|Calculated MW||16185 Da|
|Antigen Region||118-146 aa|
|Other Names||Cytidine deaminase, Cytidine aminohydrolase, CDA, CDD|
|Target/Specificity||This CDA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-146 amino acids from the C-terminal region of human CDA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.|
|Tissue Location||Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines|
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Provided below are standard protocols that you may find useful for product applications.
CDA forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. This protein is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in the CDA gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.
Laliberte J., Momparler R.L.Cancer Res. 54:5401-5407(1994)
Demontis S., Terao M.Biochim. Biophys. Acta 1443:323-333(1998)
Kuhn K., Bertling W.M., Emmrich F.Biochem. Biophys. Res. Commun. 190:1-7(1993)
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