|Application ||IHC-P, WB, E|
|Calculated MW||44825 Da|
|Antigen Region||61-87 aa|
|Other Names||Sister chromatid cohesion protein DCC1, Defective in sister chromatid cohesion protein 1 homolog, DSCC1, DCC1|
|Target/Specificity||This DCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-87 amino acids from the N-terminal region of human DCC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DCC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.|
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Provided below are standard protocols that you may find useful for product applications.
DCC1 is involved in sister chromatid cohesion establishment. The protein may act as a PCNA loader, loading PCNA onto primed templates.
Clark H.F., Gurney A.L.Genome Res. 13:2265-2270(2003)
Merkle C.J., Karnitz L.M.J. Biol. Chem. 278:30051-30056(2003)
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