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ACTC Antibody (Center)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP2875c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
ACTC Antibody (Center) - Product info | |
| Application | WB, IHC, FC
|
| Primary Accession | P62736 |
| Other Accession | P60010, P68136, P68135, P68137, P68134, P68133, P68139, P68138, P63269, P63268, P63267, P63270, Q5E9B5, A2BDB0, P63259, P63260, P63261, Q5ZMQ2, P63258, P04751, P68035, P68033, P68032, P68034, Q3ZC07, O93400, P60711, P29751, Q6QAQ1, P60710, Q4R561, P60709; |
| Reactivity | Human |
| Predicted | Bovine, Chicken, Drosophila, C.Elegans, Hamster, Mouse, Pig, Monkey, Rat, Rabbit, Xenopus, Yeast, Zebrafish |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 42009 Da |
ACTC Antibody (Center) - Additional info | |
| Gene ID 59 | |
| Other Names ACTA2; ACTSA; ACTVS; Actin, aortic smooth muscle; Alpha-actin-2; Cell growth-inhibiting gene 46 protein | |
| Target/Specificity This ACTC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197~227 amino acids from the Center region of human ACTC. | |
| Dilution WB~~1:50~100WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ACTC Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ACTC Antibody (Center) - Protein Information | |
| Name ACTA2 | |
| Synonyms ACTSA, ACTVS | |
| Function Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | |
| Cellular Location Cytoplasm, cytoskeleton. | |
ACTC Antibody (Center) - Related products
AP2875b: ACTC Antibody (C-term)
AP2875c: ACTC Antibody (Center)
RI10085: ACTA2 predesign siRNA
DC04539: Human ACTA2 cDNA Clone
LY10299a: ACTA2 Over-expression Lysate
BP2875b: ACTC Antibody (C-term) Blocking Peptide
BP2875c: ACTC Antibody (Center) Blocking Peptide
ACTC Antibody (Center) - Application data
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Western blot analysis of ACTC antibody (Center)(Cat.#AP2875c) in K562 cell line lysates (35ug/lane). ACTC (arrow) was detected using the purified Pab.
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Formalin-fixed and paraffin-embedded human skeletal muscle with ACTC Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Flow cytometric analysis of MDA-231 cells using ACTC Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
ACTC Antibody (Center) - Research Areas
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BACKGROUND
ACTC belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this protein cause aortic aneurysm familial thoracic type 6.
REFERENCES
Guo,D.C., Papke,C.L. Am. J. Hum. Genet. 84 (5), 617-627 (2009) Guo,D.C., Pannu,H. Nat. Genet. 39 (12), 1488-1493 (2007)
