|Application ||IF, WB, FC, E|
|Calculated MW||92500 Da|
|Antigen Region||737-765 aa|
|Other Names||Elongator complex protein 2, ELP2, SHINC-2, STAT3-interacting protein 1, StIP1, ELP2, STATIP1|
|Target/Specificity||This ELP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 737-765 amino acids from the C-terminal region of human ELP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ELP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the ligand-dependent activation of STAT3.|
|Cellular Location||Cytoplasm. Nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
ELP2 regulates the ligand-dependent activation of STAT3. The protein acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.
References for protein:
1.Kim,J.H., Proc. Natl. Acad. Sci. U.S.A. 99 (3), 1241-1246 (2002)
2.Hawkes,N.A., J. Biol. Chem. 277 (4), 3047-3052 (2002)
References for SY5Y (SH-SY5Y; ATCC#CRL-2266): 1. Ross RA, et al. Coordinate morphological and biochemical interconversion of human neuroblastoma cells. J. Natl. Cancer Inst. 71: 741-749, 1983. [PubMed: 6137586]; 2. Biedler JL, et al. Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res. 38: 3751-3757, 1978. [PubMed: 29704].
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