|Application ||WB, E|
|Calculated MW||31350 Da|
|Antigen Region||229-257 aa|
|Other Names||F-actin-capping protein subunit beta, CapZ beta, CAPZB|
|Target/Specificity||This CAPZB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-257 amino acids from the C-terminal region of human CAPZB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CAPZB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization.|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere|
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Provided below are standard protocols that you may find useful for product applications.
CAPZB is a member of the F-actin capping protein family. This protein is the beta subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments.
Wells,C.D., Cell 125 (3), 535-548 (2006)
Bruneel,A., Proteomics 5 (15), 3876-3884 (2005)
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