|Application ||WB, FC, E|
|Calculated MW||38274 Da|
|Antigen Region||1-30 aa|
|Other Names||Activator of 90 kDa heat shock protein ATPase homolog 1, AHA1, p38, AHSA1, C14orf3|
|Target/Specificity||This AHSA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human AHSA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AHSA1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360).|
|Cellular Location||Cytoplasm, cytosol. Endoplasmic reticulum. Note=May transiently interact with the endoplasmic reticulum|
|Tissue Location||Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
AHSA1 is a cochaperone that stimulates HSP90 ATPase activity. This protein may affect a step in the endoplasmic reticulum to Golgi trafficking.
Wang,X.,et. al., Cell 127 (4), 803-815 (2006)
Panaretou,B., et. al., Mol. Cell 10 (6), 1307-1318 (2002)
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