|Application ||WB, IHC-P, FC, E|
|Other Accession||O35244, Q2PFL9, O77834, NP_004896|
|Predicted||Bovine, Monkey, Rat|
|Calculated MW||25035 Da|
|Antigen Region||103-132 aa|
|Other Names||Peroxiredoxin-6, 1-Cys peroxiredoxin, 1-Cys PRX, 24 kDa protein, Acidic calcium-independent phospholipase A2, aiPLA2, 311-, Antioxidant protein 2, Liver 2D page spot 40, Non-selenium glutathione peroxidase, NSGPx, Red blood cells page spot 12, PRDX6, AOP2, KIAA0106|
|Target/Specificity||This PRDX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the Central region of human PRDX6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRDX6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.|
|Cellular Location||Cytoplasm. Lysosome. Cytoplasmic vesicle. Note=Also found in lung secretory organelles.|
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Provided below are standard protocols that you may find useful for product applications.
PRDX6 is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
Davila, S., et al. Genes Immun. (2010) In press :
Kubo, E., et al. Am. J. Physiol., Cell Physiol. 298 (2), C342-C354 (2010) :
Sorokina, E.M., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 297 (5), L871-L880 (2009)
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