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YWHAQ Antibody (Center)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP2929c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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YWHAQ Antibody (Center) - Product info | |
| Application | WB, IHC, FC
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| Primary Accession | P27348 |
| Other Accession | Q52M98, P68255, Q6Q6X0, P68254, Q5ZMD1, Q3SZI4 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Chicken, Rat, Rabbit, Xenopus |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 27764 Da |
YWHAQ Antibody (Center) - Additional info | |
| Gene ID 10971 | |
| Other Names YWHAQ; 14-3-3 protein theta; 14-3-3 protein T-cell; 14-3-3 protein tau; Protein HS1 | |
| Target/Specificity This YWHAQ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146~175 amino acids from the Center region of human YWHAQ. | |
| Dilution WB~~1:50~100WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions YWHAQ Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
YWHAQ Antibody (Center) - Protein Information | |
| Name YWHAQ | |
| Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner Negatively regulates the kinase activity of PDPK1 | |
| Cellular Location Cytoplasm. Note=In neurons, axonally transported to the nerve terminals | |
| Tissue Location Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement | |
YWHAQ Antibody (Center) - Related products
AP2929a: YWHAQ Antibody (N-term)
AP2929c: YWHAQ Antibody (Center)
RI15777: YWHAQ predesign siRNA
DC08057: Human YWHAQ cDNA Clone
LY11935a: YWHAQ Over-expression Lysate
BP2929a: YWHAQ Antibody (N-term) Blocking Peptide
YWHAQ Antibody (Center) - Application data
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Western blot analysis of YWHAQ Antibody (Center) (Cat. #AP2929c) in MDA-MB231, Y79 cell line and mouse brain tissue lysates (35ug/lane). YWHAQ (arrow) was detected using the purified Pab.
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Formalin-fixed and paraffin-embedded human brain tissue reacted with YWHAQ Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Flow cytometric analysis of MDA-MB468 cells using YWHAQ Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram)FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
YWHAQ Antibody (Center) - Research Areas
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BACKGROUND
YWHAQ belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs.
REFERENCES
Kuzelova,K.,et.al., J. Cell. Biochem. 106 (4), 673-681 (2009)
