|Application ||WB, IHC-P, FC, E|
|Other Accession||O08651, Q61753, Q60HD7, NP_006614|
|Predicted||Mouse, Rat, Monkey|
|Calculated MW||56651 Da|
|Antigen Region||249-277 aa|
|Other Names||D-3-phosphoglycerate dehydrogenase, 3-PGDH, PHGDH, PGDH3|
|Target/Specificity||This PHGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-277 amino acids from the Central region of human PHGDH.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PHGDH Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
3-Phosphoglycerate dehydrogenase (PHGDH; EC 188.8.131.52) catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor.
Du, H., et al. Reproduction 139(1):237-245(2010)
Burton, R.L., et al. Biochemistry 48(22):4808-4815(2009)
Kim, J.W., et al. Psychiatr. Genet. 19 (3), 161 (2009) :
Tabatabaie, L., et al. Hum. Mutat. 30(5):749-756(2009)
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