|Application ||WB, IHC-P, E|
|Calculated MW||64133 Da|
|Antigen Region||461-490 aa|
|Other Names||Heterogeneous nuclear ribonucleoprotein L, hnRNP L, HNRNPL, HNRPL|
|Target/Specificity||This HNRPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 461-490 amino acids from the C-terminal region of human HNRPL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HNRPL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.|
|Cellular Location||Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs|
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Provided below are standard protocols that you may find useful for product applications.
HNRPL is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. L is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes.
Hahm,B., et.al., FEBS Lett. 425 (3), 401-406 (1998)
Funke,B., et.al., Nucleic Acids Res. 24 (19), 3821-3828 (1996)
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