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ABL Antibody (Y251)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP3018d | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
ABL Antibody (Y251) - Product info | |
| Application | WB
|
| Primary Accession | P42684 |
| Other Accession | P00519 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 128343 Da |
ABL Antibody (Y251) - Additional info | |
| Gene ID 27 | |
| Other Names ABL2; ABLL; ARG; Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG | |
| Target/Specificity This ABL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y251 of human ABL. | |
| Dilution WB~~1:10~50WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ABL Antibody (Y251) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ABL Antibody (Y251) - Protein Information | |
| Name ABL2 | |
| Synonyms ABLL, ARG | |
| Function Non-receptor tyrosine-protein kinase that plays an ABL1- overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin- bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1 | |
| Cellular Location Cytoplasm, cytoskeleton. | |
| Tissue Location Widely expressed. | |
ABL Antibody (Y251) - Related products
AP3018a: Phospho-ABL-Y412 Antibody
BP3018d: ABL Antibody (Y251) Blocking Peptide
ABL Antibody (Y251) - Application data
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Western blot analysis of anti-ABL Antibody (Y251) (Cat.#AP3018d) in A2058 cell line lysates (35ug/lane). ABL(arrow) was detected using the purified Pab.
ABL Antibody (Y251) - Research Areas
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BACKGROUND
ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length. The peptide used to generate this antibody is 100% conserved between ABL2 and ABL1.
REFERENCES
Cao, C., et al., Biochemistry 42(35):10348-10353 (2003). Cao, C., et al., J. Biol. Chem. 278(32):29667-29675 (2003). Kruh, G.D., et al., Proc. Natl. Acad. Sci. U.S.A. 87(15):5802-5806 (1990). Kruh, G.D., et al., Science 234(4783):1545-1548 (1986). Bianchi, C., et al., FEBS Lett. 527 (1-3), 216-222 (2002).
